serum creatinine

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Creatinines are the metabolic productions of human bodies, every 20g muscular metabolism can produce 1mg creatinine. Creatinines mainly expel from human bodies by the filtration of glomerulus. Creatinines in the blood are from exogenous and endogenous. Exogenous creatinines are the meat foods productions after metabolism, endogenous creatinines are the muscular tissues productions after metabolism. At the time that the intake of meat foods is stable, and the muscular metabolism also have not big changes, the production of creatinines will be relatively constant.
Regular range of urine creatinine
8.4—1 3.25mmol/24 hours urine or 40 mg/dl --130 mg/dl are regular.
Reasons of the high creatinine
the change of concentration of the serum creatinine is mainly decided by the filtration of glomerulus (glomerular filtration rate). If filtration ability declines, the concentration of creatinine rises. Serum creatinine value higher than normal mostly means the damage of the kidneys, serum creatinine can relatively accurate the condition of the damage of renal parenchyma, but not sensitive index. Because serum creatinine rises obviously only at the time that glomerular filtration rate drop to 1/3 of the normal people. It means that because the metabolic capability of kidneys of human bodies is strong. If the kidney damage is relatively light, general people are not so much discomfort, therefore the kidneys have already damaged seriously and the serum creatinine is also rises obviously, at the time many people are nausea, vomit, swirl.
1. Metabolic disorder of sodium: High creatinine can also cause hyponatremia or hypernatronemia.
2. Metabolic disorder of potassium: High creatinine is usually accompanied with hyoerkalemia and hypokalemia.
3. Metabolic disorder of water: It includes diuresis, increase of enuresis nocturna, thirst, dry of mucous membrane, lacking in strength and so on. Or it may also include general dropsy, rises of the blood pressure, pulmonary edema, cardiac failure and so on.
4. Metabolic disturbance of aluminum, magnesium, copper, zinc, selenium and so on.
5. Renal osteopathy: Ostalgia and near-end myasthenia, the ostalgia is genetal and skeleton defornity can lead to short stature and so on.
6. Metabolic acidosis: Patients with high creatinine may have profound and long breath, anorexia, stomachache and nausea, vomit, weakness, headache, restlessness even coma and other symptoms.
7. Circulatory system lesion
8.digestive system lesion
9. Blood system lesion, such as renal anemia and so on.
10. Respiratory system lesion
reasons for the low value of serum creatinine
High serum creatinine means the abnormal kidney functions of patients. The ability of metabolic waste of the kidneys falls, some of the esoteric harmful toxin can not expel from human bodies normally. Therefore, what are the reasons for the relatively flat serum creatinines? Reasons for the flat serum creatinines are that after the kidney are violated by all kinds of pathogenies, firstly, the damaged kidneys inherent cells are phenotypic switch, which forms pathological change, stimulates the fibroblast of inner kidney changes into the myofibroblast, and also violates and stimulates inherent normal nephridial tissue, and have the same lesion, thus forms the kidney that from part to integral, and go into the organ damage period (kidney damage period). Because the kidney causes damages constantly, its function of excrete waste somewhat falls, thus making the deposit of the poisons, such as creatinine. Then it comes the blood creatinine, rising of the urea nitrogen, creatinine in the urine falls, both kidneys filtration falls. At the same time, patients also have high blood pressure, altitude edema and other symptoms of human bodies.

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